Disulfiram is a kind of alcohol-free medicine. Even after drinking a small amount of alcohol after taking this medicine, the body will have serious discomfort and achieve the purpose of abstinence. It is a white or nearly white crystalline powder, soluble in most organic solvents, slightly soluble in water, and has a solubility of 200 mg/L in pure water. Insoluble in dilute acid and dilute alkali, slightly soluble in gasoline, soluble in acetone, benzene, toluene, carbon disulfide and chloroform. Irritating to skin and mucous membranes.
Light yellow crystaline powder
UN 3077 9/PG 3
Cool,dry and hermetic place
Mechanism of action
The mechanism of action of disulfiram is that disulfiram can inhibit the acetaldehyde dehydrogenase in the liver when combined with ethanol. After the ethanol is oxidized to acetaldehyde in the body, it can no longer decompose and oxidize, resulting in the accumulation of acetaldehyde in the body. A series of reactions.
After the ethanol enters the body, it is first converted into acetaldehyde by the action of alcohol dehydrogenase in the liver. The acetaldehyde is converted into acetic acid by the action of acetaldehyde dehydrogenase, and the acetic acid enters the citric acid cycle, and finally is converted into water and carbon dioxide. Disulfiram can inhibit acetaldehyde dehydrogenase, so that acetaldehyde can not be oxidized to acetic acid, causing acetaldehyde to accumulate in the body. Acetaldehyde is a toxic substance. When the concentration of acetaldehyde in the body is increased, it can be combined with some proteins and phospholipids in the body. Nucleic acids and the like are covalently bonded to destroy the inactivation of these substances, thereby causing various discomforts in the body and exhibiting symptoms of a disulfiram-like reaction.