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Disulfiram, CAS 97-77-8

Disulfiram, CAS 97-77-8

Disulfiram is light yellow crystalline powder, using as natural rubber, butadiene rubber,butadiene rubber, butyl ruber, shunding rubber and latex superpromoter and vulcanization agent. Jinan Great Chemical Industry Co.,Ltd. is a professional Disulfiram supplier in China. If you feel interested in our product Disulfiram, please don’t hesitate to contact sale001@chemgreat.com .

Description

Description

Disulfiram is a kind of alcohol-free medicine. Even after drinking a small amount of alcohol after taking this medicine, the body will have serious discomfort and achieve the purpose of abstinence. It is a white or nearly white crystalline powder, soluble in most organic solvents, slightly soluble in water, and has a solubility of 200 mg/L in pure water. Insoluble in dilute acid and dilute alkali, slightly soluble in gasoline, soluble in acetone, benzene, toluene, carbon disulfide and chloroform. Irritating to skin and mucous membranes.

Parameter

Chemical   name

Disulfiram

Another   name

ABSTINYL
ANTIETANOL
BIS(DIETHYLTHIOCARBAMOYL) DISULFIDE
BIS(DIETHYLTHIOCARBAMYL) DISULFIDE
CONTRALIN
CRONETAL
DISULFIRAM
DRAM
DSF
ESPERAL
ETHYL THIURAD

ETHYL TUADS
NOXAL

TCB

TETD
TETRADINE

Molecular   Formular

C10H20N2S4

Molecular   Weight

296.54

Cas   No.

97-77-8

EINECS   No.

202-607-8

Appearance

Light   yellow crystaline powder

Purity

95%

Density

1.27g/cm3

Melting   point

69-71 °C(lit.)

Boiling   point

117°C

Package

25kg/bag

Hazard   Class

9

UN   No.

UN   3077 9/PG 3

Storage   Conditions

Cool,dry   and hermetic place

Mechanism of action

The mechanism of action of disulfiram is that disulfiram can inhibit the acetaldehyde dehydrogenase in the liver when combined with ethanol. After the ethanol is oxidized to acetaldehyde in the body, it can no longer decompose and oxidize, resulting in the accumulation of acetaldehyde in the body. A series of reactions.

After the ethanol enters the body, it is first converted into acetaldehyde by the action of alcohol dehydrogenase in the liver. The acetaldehyde is converted into acetic acid by the action of acetaldehyde dehydrogenase, and the acetic acid enters the citric acid cycle, and finally is converted into water and carbon dioxide. Disulfiram can inhibit acetaldehyde dehydrogenase, so that acetaldehyde can not be oxidized to acetic acid, causing acetaldehyde to accumulate in the body. Acetaldehyde is a toxic substance. When the concentration of acetaldehyde in the body is increased, it can be combined with some proteins and phospholipids in the body. Nucleic acids and the like are covalently bonded to destroy the inactivation of these substances, thereby causing various discomforts in the body and exhibiting symptoms of a disulfiram-like reaction.

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