Di-tert-butyl dicarbonate (Diboc) is a novel amino-protecting agent used in organic synthesis to introduce a tert-butoxycarbonyl (BOC) protectant, especially for amino-protection of amino acids. Widely used in the synthesis of pharmaceuticals, protein and peptide synthesis, biochemistry, food, cosmetics and other products. The finished product is a colorless crystal or a colorless liquid, and is dissolved in an organic solvent such as tetrahydrofuran, n-hexane, benzene or chloroform, and slightly soluble in water.
BOC-anhydride, DBDC , EINECS 246-240-1
Transparent crystal or liquid
23 ℃ (lit.)
235.8±0.0 °C at 760 mmHg
UN 2929 6.1/PG 1
Cool,dry and hermetic place
Description of use
Pharmaceutical and organic synthesis intermediates are important amino protecting agents for the synthesis of pharmaceutical and agrochemical products.
Used as an intermediate in medicine and organic synthesis, it is an important amino protecting agent for the synthesis of pharmaceutical and agrochemical products.
In organic chemical reactions, tert-butoxycarbonylation reagents, which are often used as substrates for amines, phenols, thiols, amides, lactams, carbamates, etc., have a fast reaction rate and a relatively high yield. Tert-butoxycarbonylation (protection of functional groups); Because of its poor stability, the acid halide reagent is widely used as a protecting group for amino groups under acidic conditions (eg, hydrochloric acid, trifluoroacetic acid, etc.) ) can be taken off. Fatty amines, alicyclic amines, aromatic amines, and heterocyclic amines are all capable of reacting with (Boc).