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Chemical properties
Jun 22, 2017

Trifluoroacetic acid (TFA) is a strong carboxylic acid. PKa = -0.23. With only minor toxicity, TFA undergoes microbial degradation to produce greenhouse gases CHF3.

Affected by the absorption of trifluoromethyl and have a strong acid, acidic than acetic acid ten thousand times. Trifluoroacetic acid in the presence of aniline decomposition into fluorine and carbon dioxide.

Can be reduced by sodium borohydride or lithium aluminum hydride to trifluoroacetaldehyde and trifluoroethanol. Stabilized at 205 ° C or higher, esters and amide derivatives are easily hydrolyzed, and saccharides, amino acids and peptide derivatives can be prepared in the form of acids or anhydrides. Easy in the role of phosphorus pentahydide dehydration for trifluoroacetic anhydride.

Chemical reaction formula: CF3COF + H2O = CF3CO2H + HF