Trifluoroacetic acid is a good solvent for many organic compounds, such as in combination with carbon disulfide, to solubilize proteins. It is also an excellent solvent for organic reactions and can be obtained as a result which is difficult to obtain in a general solvent. For example, when quinoline is catalytically hydrogenated in a general solvent, the pyridine ring is preferentially hydrogenated, but the benzene ring is preferentially hydrogenated in trifluoroacetic acid. Trifluoroacetic acid is decomposed into fluoroform and carbon dioxide in the presence of aniline.
Colorless volatile fuming liquid
25KG/NET Fiber Drum with double lined plastic bag inside
Cool,dry and hermetic place
Used for pharmaceutical, pesticide intermediates, biochemical reagents, organic synthesis reagents
Trifluoroacetic acid (TFA) is a strong carboxylic acid with pKa = 0.23, which stimulates human tissues and skin. Only mild toxicity, but enrichment in non-flowing surface water affects agricultural and aquatic systems, and TFA undergoes microbial degradation to produce greenhouse gas CHF3.
It is strongly acidic due to the influence of the electron-withdrawing trifluoromethyl group, and the acidity is 100,000 times stronger than that of acetic acid. Trifluoroacetic acid is decomposed into fluoroform and carbon dioxide in the presence of aniline.
It can be reduced to trifluoroacetaldehyde and trifluoroethanol by sodium borohydride or lithium aluminum hydride. Stable at 205 ° C or higher, esters and amide derivatives are easily hydrolyzed, so that sugars, amino acids and peptide derivatives can be obtained in the form of an acid or an acid anhydride. It is easy to dehydrate to trifluoroacetic anhydride under the action of phosphorus pentoxide.
Trifluoroacetic acid is an important aliphatic fluoro intermediate. Due to its special structure of trifluoromethyl group, it has different properties from other alcohols and can participate in various organic synthesis reactions, especially for the synthesis of fluorine-containing medicines. In the fields of pesticides and dyes, domestic and international demand is increasing, and it has become one of the important intermediates of fluorine-containing fine chemicals.