JINAN GREAT CHEMICAL INDUSTRY CO., LTD

TEL: +86-531-58668191

FAX:+86-531-69987825

MOB: +8618954127179

E-mail: wendy@chemgreat.com

ADD: Environmental Science and Technology Parks, Jinan,Shandong Province, China

Trifluoroacetic Acid(TFA)CAS No 76-05-1 Kyselina Trifluoroctova

Trifluoroacetic Acid(TFA)CAS No 76-05-1 Kyselina Trifluoroctova

Trifluoroacetic acid Trifluoroacetic acid CAS 76-05-1 is colorless volatile fuming liquid, and it is widely used for pharmaceutical,pesticide intermediates,biochemical reagents, organic synthesis reagents.If you are in need of trifluoroacetic acid,please feel free to contact sale001@chemgreat.com...

Description

Description

Trifluoroacetic acid is a good solvent for many organic compounds, such as in combination with carbon disulfide, to solubilize proteins. It is also an excellent solvent for organic reactions and can be obtained as a result which is difficult to obtain in a general solvent. For example, when quinoline is catalytically hydrogenated in a general solvent, the pyridine ring is preferentially hydrogenated, but the benzene ring is preferentially hydrogenated in trifluoroacetic acid. Trifluoroacetic acid is decomposed into fluoroform and carbon dioxide in the presence of aniline.

Parameter

Chemical name

Trifluoroacetic acid

Molecular Structure

 

2889.gif 

Molecular Formular

C2HF3O2

Molecular Weight

114.02

Cas No.

76-05-1

EINECS No.

200-929-3

Appearance

Colorless volatile fuming liquid

Purity

>=99.5%

Melting point

-15.6℃ 

Boiling point

 71.1℃

Package

25KG/NET Fiber Drum with double lined plastic bag inside

Hazard Class

C:Corrosive

UN No.

UN2699

Storage Conditions

Cool,dry and hermetic place

Application

 

Used for pharmaceutical, pesticide intermediates, biochemical reagents,  organic synthesis reagents

Chemical properties

Trifluoroacetic acid (TFA) is a strong carboxylic acid with pKa = 0.23, which stimulates human tissues and skin. Only mild toxicity, but enrichment in non-flowing surface water affects agricultural and aquatic systems, and TFA undergoes microbial degradation to produce greenhouse gas CHF3.

It is strongly acidic due to the influence of the electron-withdrawing trifluoromethyl group, and the acidity is 100,000 times stronger than that of acetic acid. Trifluoroacetic acid is decomposed into fluoroform and carbon dioxide in the presence of aniline.

It can be reduced to trifluoroacetaldehyde and trifluoroethanol by sodium borohydride or lithium aluminum hydride. Stable at 205 ° C or higher, esters and amide derivatives are easily hydrolyzed, so that sugars, amino acids and peptide derivatives can be obtained in the form of an acid or an acid anhydride. It is easy to dehydrate to trifluoroacetic anhydride under the action of phosphorus pentoxide.

Trifluoroacetic acid is an important aliphatic fluoro intermediate. Due to its special structure of trifluoromethyl group, it has different properties from other alcohols and can participate in various organic synthesis reactions, especially for the synthesis of fluorine-containing medicines. In the fields of pesticides and dyes, domestic and international demand is increasing, and it has become one of the important intermediates of fluorine-containing fine chemicals.

Related Products

Feedback