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Gemcitabine CAS 95058-81-4;2'-Deoxy-2',2'-difluoro-D-cytidine

Gemcitabine CAS 95058-81-4;2'-Deoxy-2',2'-difluoro-D-cytidine

Gemcitabine is used for the treatment of advanced non-small cell lung cancer.We are professional Gemcitabine manufacturer and supplier in China.If you want to know more information,please feel free to contact sale001@chemgreat.com.

Description

Description

Gemcitabine is a new cytosine derivative. Like cytarabine, it enters the human body and is activated by deoxycytidine kinase and metabolized by cytidine deaminase. This product is a pyrimidine antitumor drug, the mechanism of action is the same as that of cytarabine, and its main metabolite incorporates DNA into the cell, mainly in the G1/S phase. However, the difference is that difluorodeoxycytidine inhibits ribonucleotide reductase in addition to DNA, resulting in a decrease in intracellular deoxynucleoside triphosphate; another difference from cytarabine is that it inhibits deoxygenation. Pyrimidine deaminase reduces the degradation of intracellular metabolites and has a self-enhancing effect. Clinically, this product and cytarabine have different anti-tumor profiles and are effective against a variety of solid tumors.

Application

For patients with advanced pancreatic cancer, as a second-line medication after fluorouracil failure, it can improve the quality of life of patients; secondly, it is a first-line application for locally advanced (stage III) and already metastatic (stage IV) non-small cell lung cancer. Recent data indicate that this product has palliative effects on ovarian cancer, breast cancer, bladder cancer, cervical cancer, liver cancer, biliary tract cancer, nasopharyngeal cancer, testicular tumor, lymphoma, mesothelioma and head and neck cancer.

Parameter

Chemical name

Gemcitabine

Molecular Structure

图片27.jpg

Molecular Formular

C9H11F2N3O4

Molecular Weight

263.1981

Cas No.

95058-81-4

Appearance

White powder

Purity

98%

Melting point

168.64°C

Boiling point

482.693°C at 760 mmHg

Package

100g;500g; 1kg

Storage Conditions

Cool,dry and hermetic place

Adverse reactions

The dose-limiting toxicity of this product is myelosuppression, which is more common in both neutrophils and platelets. The 4-week regimen (administered on days 1, 8, and 15) had a greater effect on blood levels than the 3-week regimen (administered on days 1 and 8). This product often causes mild to moderate digestive system reactions such as constipation, diarrhea, stomatitis and so on. In addition, it can cause fever, rash, and flu-like symptoms. A small number of patients may have proteinuria, hematuria, liver and kidney dysfunction and difficulty breathing.

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