Capecitabine is rapidly absorbed by the intestinal mucosa after oral administration, and then converted into an inactive intermediate 5'-deoxy-5' fluorocytidine in the liver by carboxylesterase, followed by cytidine removal from liver and tumor tissues. The action of the aminoase is converted to 5'-deoxy-5' fluorouridine and finally catalyzed by thymidine phosphorylase to fluorouracil (5-FU) in tumor tissues.
437.874°C at 760 mmHg
Store in original container in a cool dark place
Can have diarrhea, nausea, vomiting, gastritis. Hand and foot syndrome occurs in almost half of patients, manifested as: numbness, dullness, paresthesia, tingling, painlessness and pain, skin swelling and erythema, blisters or severe pain. Dermatitis and hair loss are more common. Often fatigue, mucositis, fever, weakness, lethargy, as well as headache, taste disorders, dizziness, insomnia, neutropenia, anemia, dehydration.